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"pi": "吴忠寿",
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"no": 459,
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"pi": "孟颖",
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"no": 460,
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"unit": "浙江大学",
"pi": "唐敏悦",
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"no": 463,
"unit": "浙江大学",
"pi": "周艳",
"name": "病原菌D-E家族ADP-核糖基转移酶效应蛋白的功能和机制",
"code": "Z26H190005",
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"disc": "医学",
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"pi": "张巧艳",
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"no": 466,
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"no": 467,
"unit": "温州医科大学",
"pi": "王旭",
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"code": "Z26H090009",
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"no": 471,
"unit": "浙江大学",
"pi": "黄华琼",
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"no": 472,
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"pi": "陈一杰",
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"code": "Z26H180002",
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"no": 473,
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"pi": "熊阳",
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"no": 654,
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"no": 662,
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"no": 672,
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"no": 681,
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"no": 687,
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},
{
"no": 1005,
"unit": "浙江大学",
"pi": "叶仕炬",
"name": "心肌细胞中CDK9与NF-κB P65亚基的直接互作调控病理性心室重构的分子机制研究",
"code": "MS26H020024",
"cat": "探索项目",
"disc": "医学",
"lines": "细胞/类器官",
"ev": "细胞",
"amt26": 22.9,
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},
{
"no": 1007,
"unit": "浙江大学",
"pi": "王俊",
"name": "TLR7突变导致的自身炎症性疾病研究",
"code": "MS26H100006",
"cat": "探索项目",
"disc": "医学",
"lines": "未命中",
"ev": "",
"amt26": 22.9,
"amt25": 14.76,
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"tier": "B",
"proj_score": 2,
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"act": "确认课题组采购主体与预算年度；先寄试用装（项目：TLR7突变导致的自身炎症性疾病研究）"
},
{
"no": 1008,
"unit": "浙江大学",
"pi": "蒋心驰",
"name": "“清源疏流”双功能干细胞膜仿生囊泡构建及其靶向修复血脑屏障的研究",
"code": "MS26H300038",
"cat": "探索项目",
"disc": "医学",
"lines": "细胞/类器官",
"ev": "干细胞、细胞",
"amt26": 22.9,
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"act_n": 559,
"act_last": "2026-10-22",
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"owner": "侯海瑜",
"score": 6,
"tier": "B",
"proj_score": 3,
"unit_score": 3,
"act": "确认课题组采购主体与预算年度；先寄试用装（项目：“清源疏流”双功能干细胞膜仿生囊泡构建及其靶向修）"
},
{
"no": 1010,
"unit": "浙江大学",
"pi": "国）黄胜利",
"name": "牛磺酸枝接γ-聚谷氨酸仿生水凝胶在角膜无瘢痕修复和神经再生中的作用及机制研究",
"code": "MS26H120013",
"cat": "探索项目",
"disc": "医学",
"lines": "未命中",
"ev": "",
"amt26": 22.9,
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"owner": "侯海瑜",
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"tier": "B",
"proj_score": 2,
"unit_score": 3,
"act": "确认课题组采购主体与预算年度；先寄试用装（项目：牛磺酸枝接γ-聚谷氨酸仿生水凝胶在角膜无瘢痕修复）"
},
{
"no": 1011,
"unit": "杭州医学院",
"pi": "胡晓歌",
"name": "PSMD7-IGF2BP3正反馈信号轴在肝癌恶性进展中的作用及分子机制研究",
"code": "MS26H160092",
"cat": "探索项目",
"disc": "医学",
"lines": "未命中",
"ev": "",
"amt26": 0.04,
"amt25": 0.2,
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"act_n": 4,
"act_last": "2026-09-20",
"act90": 4,
"owner": "侯海瑜",
"score": 3,
"tier": "C",
"proj_score": 2,
"unit_score": 1,
"act": "纳入单位级年度拜访清单，暂不单独立项（项目：PSMD7-IGF2BP3正反馈信号轴在肝癌恶性）"
},
{
"no": 1012,
"unit": "浙江大学",
"pi": "熊枭",
"name": "靶向神经元的工程化外泌体递送Tau单抗治疗阿尔茨海默病的研究",
"code": "MS26H090053",
"cat": "探索项目",
"disc": "医学",
"lines": "mRNA/核酸药",
"ev": "递送",
"amt26": 22.9,
"amt25": 14.76,
"ords26": 308,
"last_ship": "2040-04-09",
"act_n": 559,
"act_last": "2026-10-22",
"act90": 456,
"owner": "侯海瑜",
"score": 6,
"tier": "B",
"proj_score": 3,
"unit_score": 3,
"act": "确认课题组采购主体与预算年度；先寄试用装（项目：靶向神经元的工程化外泌体递送Tau单抗治疗阿尔茨）"
},
{
"no": 1015,
"unit": "浙江大学",
"pi": "史亮",
"name": "circNSMASE3-乳酸脱氢酶复合体诱导肝癌NK细胞免疫监视逃逸的机制研究",
"code": "MS26H160105",
"cat": "探索项目",
"disc": "医学",
"lines": "蛋白表达纯化、细胞/类器官",
"ev": "细胞、酶",
"amt26": 22.9,
"amt25": 14.76,
"ords26": 308,
"last_ship": "2040-04-09",
"act_n": 559,
"act_last": "2026-10-22",
"act90": 456,
"owner": "侯海瑜",
"score": 7,
"tier": "A",
"proj_score": 4,
"unit_score": 3,
"act": "核对是否已建课题组档案；带 1–2 个同方向货号做技术交流（项目：circNSMASE3-乳酸脱氢酶复合体诱导肝癌）"
},
{
"no": 1016,
"unit": "浙江大学",
"pi": "金岚菲",
"name": "锑暴露通过调控巨噬细胞铁稳态和NLRs信号通路加重结直肠炎的作用机制",
"code": "MS26H260026",
"cat": "探索项目",
"disc": "医学",
"lines": "细胞/类器官",
"ev": "细胞",
"amt26": 22.9,
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"act_n": 559,
"act_last": "2026-10-22",
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"owner": "侯海瑜",
"score": 6,
"tier": "B",
"proj_score": 3,
"unit_score": 3,
"act": "确认课题组采购主体与预算年度；先寄试用装（项目：锑暴露通过调控巨噬细胞铁稳态和NLRs信号通路加）"
},
{
"no": 1017,
"unit": "浙江大学",
"pi": "张子亦",
"name": "基于GlyRs-CEPT1轴介导的甘油酯-磷脂代谢流重编程改善胰岛β细胞增殖与功能的机制研究",
"code": "MS26H070018",
"cat": "探索项目",
"disc": "医学",
"lines": "细胞/类器官",
"ev": "细胞",
"amt26": 22.9,
"amt25": 14.76,
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"last_ship": "2040-04-09",
"act_n": 559,
"act_last": "2026-10-22",
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"owner": "侯海瑜",
"score": 6,
"tier": "B",
"proj_score": 3,
"unit_score": 3,
"act": "确认课题组采购主体与预算年度；先寄试用装（项目：基于GlyRs-CEPT1轴介导的甘油酯-磷脂代）"
},
{
"no": 1018,
"unit": "温州医科大学",
"pi": "徐丹",
"name": "“代谢-灌注耦合”视角下屈光参差性弱视的视网膜功能失衡及训练可塑性研究",
"code": "MS26H120009",
"cat": "探索项目",
"disc": "医学",
"lines": "未命中",
"ev": "",
"amt26": 2.15,
"amt25": 2.95,
"ords26": 73,
"last_ship": "2026-10-21",
"act_n": 262,
"act_last": "2026-10-22",
"act90": 236,
"owner": "袁殿果",
"score": 4,
"tier": "C",
"proj_score": 2,
"unit_score": 2,
"act": "纳入单位级年度拜访清单，暂不单独立项（项目：“代谢-灌注耦合”视角下屈光参差性弱视的视网膜功）"
},
{
"no": 1019,
"unit": "杭州师范大学",
"pi": "王月",
"name": "基于表观因子筛选的SN-38抗体偶联药物在三阴性乳腺癌中的增敏策略与机制研究",
"code": "MS26H160020",
"cat": "探索项目",
"disc": "医学",
"lines": "蛋白表达纯化",
"ev": "抗体",
"amt26": 1.1,
"amt25": 0.47,
"ords26": 48,
"last_ship": "2026-09-28",
"act_n": 105,
"act_last": "2026-09-28",
"act90": 86,
"owner": "侯海瑜",
"score": 5,
"tier": "B",
"proj_score": 3,
"unit_score": 2,
"act": "确认课题组采购主体与预算年度；先寄试用装（项目：基于表观因子筛选的SN-38抗体偶联药物在三阴性）"
},
{
"no": 1020,
"unit": "浙江中医药大学",
"pi": "侯晓丽",
"name": "葛根化浊汤通过CKMT2介导的无效肌酸循环促进米色脂肪细胞产热",
"code": "MS26H290022",
"cat": "探索项目",
"disc": "医学",
"lines": "细胞/类器官",
"ev": "细胞",
"amt26": 0.55,
"amt25": 3.29,
"ords26": 46,
"last_ship": "2026-10-10",
"act_n": 107,
"act_last": "2026-10-20",
"act90": 88,
"owner": "叶信福",
"score": 4,
"tier": "C",
"proj_score": 3,
"unit_score": 1,
"act": "纳入单位级年度拜访清单，暂不单独立项（项目：葛根化浊汤通过CKMT2介导的无效肌酸循环促进米）"
},
{
"no": 1021,
"unit": "浙江大学",
"pi": "周逸蒋",
"name": "CD34+干/祖细胞在心梗后淋巴管新生中的作用及机制研究",
"code": "MS26H020039",
"cat": "探索项目",
"disc": "医学",
"lines": "细胞/类器官",
"ev": "细胞",
"amt26": 22.9,
"amt25": 14.76,
"ords26": 308,
"last_ship": "2040-04-09",
"act_n": 559,
"act_last": "2026-10-22",
"act90": 456,
"owner": "侯海瑜",
"score": 6,
"tier": "B",
"proj_score": 3,
"unit_score": 3,
"act": "确认课题组采购主体与预算年度；先寄试用装（项目：CD34+干/祖细胞在心梗后淋巴管新生中的作用及）"
},
{
"no": 1023,
"unit": "浙江大学",
"pi": "许佳慧",
"name": "MECR通过重塑鞘脂代谢调控三阴性乳腺癌化疗敏感性的功能与机制研究",
"code": "MS26H160108",
"cat": "探索项目",
"disc": "医学",
"lines": "未命中",
"ev": "",
"amt26": 22.9,
"amt25": 14.76,
"ords26": 308,
"last_ship": "2040-04-09",
"act_n": 559,
"act_last": "2026-10-22",
"act90": 456,
"owner": "侯海瑜",
"score": 5,
"tier": "B",
"proj_score": 2,
"unit_score": 3,
"act": "确认课题组采购主体与预算年度；先寄试用装（项目：MECR通过重塑鞘脂代谢调控三阴性乳腺癌化疗敏感）"
},
{
"no": 1024,
"unit": "温州医科大学",
"pi": "杨波",
"name": "EPA通过Ang-(1-7)-Mas轴调控Ang II诱导的巨噬细胞极化在减轻血管重塑中的机制研究",
"code": "MS26H260012",
"cat": "探索项目",
"disc": "医学",
"lines": "细胞/类器官",
"ev": "细胞",
"amt26": 2.15,
"amt25": 2.95,
"ords26": 73,
"last_ship": "2026-10-21",
"act_n": 262,
"act_last": "2026-10-22",
"act90": 236,
"owner": "袁殿果",
"score": 5,
"tier": "B",
"proj_score": 3,
"unit_score": 2,
"act": "确认课题组采购主体与预算年度；先寄试用装（项目：EPA通过Ang-(1-7)-Mas轴调控Ang）"
},
{
"no": 1025,
"unit": "浙江大学",
"pi": "蒲祥元",
"name": "SR-B1/occludin互作介导内皮旁细胞途径致动脉粥样硬化机制研究",
"code": "MS26H020028",
"cat": "探索项目",
"disc": "医学",
"lines": "细胞/类器官",
"ev": "细胞",
"amt26": 22.9,
"amt25": 14.76,
"ords26": 308,
"last_ship": "2040-04-09",
"act_n": 559,
"act_last": "2026-10-22",
"act90": 456,
"owner": "侯海瑜",
"score": 6,
"tier": "B",
"proj_score": 3,
"unit_score": 3,
"act": "确认课题组采购主体与预算年度；先寄试用装（项目：SR-B1/occludin互作介导内皮旁细胞途）"
},
{
"no": 1026,
"unit": "浙江大学",
"pi": "黄东骅",
"name": "Sema3A/XIAP/Pax6介导的“神经-免疫”轴调控骨修复中炎症转归的作用及机制研究",
"code": "MS26H060029",
"cat": "探索项目",
"disc": "医学",
"lines": "未命中",
"ev": "",
"amt26": 22.9,
"amt25": 14.76,
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"last_ship": "2040-04-09",
"act_n": 559,
"act_last": "2026-10-22",
"act90": 456,
"owner": "侯海瑜",
"score": 5,
"tier": "B",
"proj_score": 2,
"unit_score": 3,
"act": "确认课题组采购主体与预算年度；先寄试用装（项目：Sema3A/XIAP/Pax6介导的“神经-免）"
},
{
"no": 1028,
"unit": "浙江中医药大学",
"pi": "王萍儿",
"name": "滑膜M1巨噬细胞旁分泌激活NTRK1/p53/PGC-1α信号促进KOA软骨细胞脂肪酸氧化的分子机制及补骨壮筋汤干预的",
"code": "MS26H270034",
"cat": "探索项目",
"disc": "医学",
"lines": "细胞/类器官",
"ev": "细胞",
"amt26": 0.55,
"amt25": 3.29,
"ords26": 46,
"last_ship": "2026-10-10",
"act_n": 107,
"act_last": "2026-10-20",
"act90": 88,
"owner": "叶信福",
"score": 4,
"tier": "C",
"proj_score": 3,
"unit_score": 1,
"act": "纳入单位级年度拜访清单，暂不单独立项（项目：滑膜M1巨噬细胞旁分泌激活NTRK1/p53/P）"
},
{
"no": 1030,
"unit": "温州医科大学",
"pi": "郑以孜",
"name": "心磷脂酰基转移酶LCLAT1通过重塑脂酰谱活化线粒体PI3K/AKT通路促进乳腺癌进展的机制研究",
"code": "MS26H160030",
"cat": "探索项目",
"disc": "医学",
"lines": "蛋白表达纯化",
"ev": "酶",
"amt26": 2.15,
"amt25": 2.95,
"ords26": 73,
"last_ship": "2026-10-21",
"act_n": 262,
"act_last": "2026-10-22",
"act90": 236,
"owner": "袁殿果",
"score": 5,
"tier": "B",
"proj_score": 3,
"unit_score": 2,
"act": "确认课题组采购主体与预算年度；先寄试用装（项目：心磷脂酰基转移酶LCLAT1通过重塑脂酰谱活化线）"
},
{
"no": 1032,
"unit": "浙江大学",
"pi": "吕萍萍",
"name": "THBS2-WIF1-WNT信号轴在卵母细胞发生发育中的调控机制研究",
"code": "MS26H040032",
"cat": "探索项目",
"disc": "医学",
"lines": "细胞/类器官",
"ev": "细胞",
"amt26": 22.9,
"amt25": 14.76,
"ords26": 308,
"last_ship": "2040-04-09",
"act_n": 559,
"act_last": "2026-10-22",
"act90": 456,
"owner": "侯海瑜",
"score": 6,
"tier": "B",
"proj_score": 3,
"unit_score": 3,
"act": "确认课题组采购主体与预算年度；先寄试用装（项目：THBS2-WIF1-WNT信号轴在卵母细胞发生）"
},
{
"no": 1033,
"unit": "杭州医学院",
"pi": "夏文杰",
"name": "谷氨酰胺通过circBACH1 m6A甲基化修饰介导乳腺癌紫杉醇耐药的机制研究",
"code": "MS26H160099",
"cat": "探索项目",
"disc": "医学",
"lines": "未命中",
"ev": "",
"amt26": 0.04,
"amt25": 0.2,
"ords26": 9,
"last_ship": "2026-05-19",
"act_n": 4,
"act_last": "2026-09-20",
"act90": 4,
"owner": "侯海瑜",
"score": 3,
"tier": "C",
"proj_score": 2,
"unit_score": 1,
"act": "纳入单位级年度拜访清单，暂不单独立项（项目：谷氨酰胺通过circBACH1 m6A甲基化修饰）"
},
{
"no": 1034,
"unit": "浙江大学",
"pi": "沈志鹏",
"name": "BRD4-P-TEFb异常激活驱动髓母细胞瘤干细胞超级增强子网络的分子机制与靶向干预",
"code": "MS26H160151",
"cat": "探索项目",
"disc": "医学",
"lines": "细胞/类器官",
"ev": "干细胞、细胞",
"amt26": 22.9,
"amt25": 14.76,
"ords26": 308,
"last_ship": "2040-04-09",
"act_n": 559,
"act_last": "2026-10-22",
"act90": 456,
"owner": "侯海瑜",
"score": 6,
"tier": "B",
"proj_score": 3,
"unit_score": 3,
"act": "确认课题组采购主体与预算年度；先寄试用装（项目：BRD4-P-TEFb异常激活驱动髓母细胞瘤干细）"
},
{
"no": 1035,
"unit": "浙江大学",
"pi": "王盛东",
"name": "骨肉瘤细胞通过线粒体转移调控PMN-MDSC铁代谢促进化疗抵抗的作用与机制研究",
"code": "MS26H160112",
"cat": "探索项目",
"disc": "医学",
"lines": "细胞/类器官",
"ev": "细胞",
"amt26": 22.9,
"amt25": 14.76,
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"owner": "侯海瑜",
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"act": "确认课题组采购主体与预算年度；先寄试用装（项目：骨肉瘤细胞通过线粒体转移调控PMN-MDSC铁代）"
},
{
"no": 1038,
"unit": "浙江大学",
"pi": "陈建忠",
"name": "多模态语言算法构建化合物毒性预测模型",
"code": "MS26H300037",
"cat": "探索项目",
"disc": "医学",
"lines": "未命中",
"ev": "",
"amt26": 22.9,
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"last_ship": "2040-04-09",
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"owner": "侯海瑜",
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"tier": "B",
"proj_score": 2,
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"act": "确认课题组采购主体与预算年度；先寄试用装（项目：多模态语言算法构建化合物毒性预测模型）"
},
{
"no": 1039,
"unit": "浙江大学",
"pi": "糜家睿",
"name": "肝胆管上皮细胞可塑性及her9基因在肝胆管介导的肝再生中的作用和机制研究",
"code": "MS26H030033",
"cat": "探索项目",
"disc": "医学",
"lines": "细胞/类器官",
"ev": "细胞",
"amt26": 22.9,
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"last_ship": "2040-04-09",
"act_n": 559,
"act_last": "2026-10-22",
"act90": 456,
"owner": "侯海瑜",
"score": 6,
"tier": "B",
"proj_score": 3,
"unit_score": 3,
"act": "确认课题组采购主体与预算年度；先寄试用装（项目：肝胆管上皮细胞可塑性及her9基因在肝胆管介导的）"
},
{
"no": 1041,
"unit": "国科大杭州高等研究院",
"pi": "孟慧",
"name": "基于文本驱动的小样本腹部CT影像多类别肿瘤精准分割技术研究",
"code": "MS26H180001",
"cat": "探索项目",
"disc": "医学",
"lines": "未命中",
"ev": "",
"amt26": 0.51,
"amt25": 0.0,
"ords26": 45,
"last_ship": "2026-10-21",
"act_n": 89,
"act_last": "2026-10-21",
"act90": 75,
"owner": "袁殿果",
"score": 3,
"tier": "C",
"proj_score": 2,
"unit_score": 1,
"act": "纳入单位级年度拜访清单，暂不单独立项（项目：基于文本驱动的小样本腹部CT影像多类别肿瘤精准分）"
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{
"no": 1042,
"unit": "浙江中医药大学",
"pi": "吴德鸿",
"name": "性激素差异性调控Gordonibacter–鞣花酸代谢通路介导SLE性别二态性的机制及狼疮定干预研究",
"code": "MS26H270029",
"cat": "探索项目",
"disc": "医学",
"lines": "未命中",
"ev": "",
"amt26": 0.55,
"amt25": 3.29,
"ords26": 46,
"last_ship": "2026-10-10",
"act_n": 107,
"act_last": "2026-10-20",
"act90": 88,
"owner": "叶信福",
"score": 3,
"tier": "C",
"proj_score": 2,
"unit_score": 1,
"act": "纳入单位级年度拜访清单，暂不单独立项（项目：性激素差异性调控Gordonibacter–鞣花）"
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{
"no": 1043,
"unit": "浙江大学",
"pi": "杜文昕",
"name": "全新TSC22D3融合促进急性淋巴细胞白血病化疗抵抗的机制及干预药物研究",
"code": "MS26H310038",
"cat": "探索项目",
"disc": "医学",
"lines": "细胞/类器官",
"ev": "细胞",
"amt26": 22.9,
"amt25": 14.76,
"ords26": 308,
"last_ship": "2040-04-09",
"act_n": 559,
"act_last": "2026-10-22",
"act90": 456,
"owner": "侯海瑜",
"score": 6,
"tier": "B",
"proj_score": 3,
"unit_score": 3,
"act": "确认课题组采购主体与预算年度；先寄试用装（项目：全新TSC22D3融合促进急性淋巴细胞白血病化疗）"
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{
"no": 1045,
"unit": "温州医科大学",
"pi": "左志贵",
"name": "结肠上皮细胞来源FGF9通过FGFR2/DUSP5/NF-κB轴调控炎症性肠损伤的机制研究",
"code": "MS26H030010",
"cat": "探索项目",
"disc": "医学",
"lines": "细胞/类器官",
"ev": "细胞",
"amt26": 2.15,
"amt25": 2.95,
"ords26": 73,
"last_ship": "2026-10-21",
"act_n": 262,
"act_last": "2026-10-22",
"act90": 236,
"owner": "袁殿果",
"score": 5,
"tier": "B",
"proj_score": 3,
"unit_score": 2,
"act": "确认课题组采购主体与预算年度；先寄试用装（项目：结肠上皮细胞来源FGF9通过FGFR2/DUSP）"
},
{
"no": 1046,
"unit": "温州医科大学",
"pi": "应磊",
"name": "线粒体蛋白酶ATP23调控线粒体稳态在对乙酰氨基酚所致小鼠急性肝损伤中的作用及机制研究",
"code": "MS26H030013",
"cat": "探索项目",
"disc": "医学",
"lines": "蛋白表达纯化",
"ev": "蛋白、酶",
"amt26": 2.15,
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"ords26": 73,
"last_ship": "2026-10-21",
"act_n": 262,
"act_last": "2026-10-22",
"act90": 236,
"owner": "袁殿果",
"score": 5,
"tier": "B",
"proj_score": 3,
"unit_score": 2,
"act": "确认课题组采购主体与预算年度；先寄试用装（项目：线粒体蛋白酶ATP23调控线粒体稳态在对乙酰氨基）"
},
{
"no": 1048,
"unit": "浙江中医药大学",
"pi": "刘华杨",
"name": "膜靶向自组装多肽纳米材料的设计及其在耐药性细菌脑膜炎治疗中的应用研究",
"code": "MS26H180021",
"cat": "探索项目",
"disc": "医学",
"lines": "蛋白表达纯化",
"ev": "多肽",
"amt26": 0.55,
"amt25": 3.29,
"ords26": 46,
"last_ship": "2026-10-10",
"act_n": 107,
"act_last": "2026-10-20",
"act90": 88,
"owner": "叶信福",
"score": 4,
"tier": "C",
"proj_score": 3,
"unit_score": 1,
"act": "纳入单位级年度拜访清单，暂不单独立项（项目：膜靶向自组装多肽纳米材料的设计及其在耐药性细菌脑）"
},
{
"no": 1049,
"unit": "浙江大学",
"pi": "林锦雯",
"name": "工程化树突状细胞胶囊归巢淋巴组织诱导肾移植免疫耐受研究",
"code": "MS26H050012",
"cat": "探索项目",
"disc": "医学",
"lines": "细胞/类器官",
"ev": "细胞",
"amt26": 22.9,
"amt25": 14.76,
"ords26": 308,
"last_ship": "2040-04-09",
"act_n": 559,
"act_last": "2026-10-22",
"act90": 456,
"owner": "侯海瑜",
"score": 6,
"tier": "B",
"proj_score": 3,
"unit_score": 3,
"act": "确认课题组采购主体与预算年度；先寄试用装（项目：工程化树突状细胞胶囊归巢淋巴组织诱导肾移植免疫耐）"
},
{
"no": 1050,
"unit": "浙江大学",
"pi": "龚旭波",
"name": "2E-21调控c-Myc/PGC-1α/OXPHOS通路抗MYC/BCL2双打击淋巴瘤的机制研究",
"code": "MS26H080022",
"cat": "探索项目",
"disc": "医学",
"lines": "未命中",
"ev": "",
"amt26": 22.9,
"amt25": 14.76,
"ords26": 308,
"last_ship": "2040-04-09",
"act_n": 559,
"act_last": "2026-10-22",
"act90": 456,
"owner": "侯海瑜",
"score": 5,
"tier": "B",
"proj_score": 2,
"unit_score": 3,
"act": "确认课题组采购主体与预算年度；先寄试用装（项目：2E-21调控c-Myc/PGC-1α/OXPH）"
},
{
"no": 1052,
"unit": "浙江大学",
"pi": "杨丽君",
"name": "基于T细胞功能抑制的AI增效筛选模型发现溃疡性结肠炎潜在治疗药物叶黄素",
"code": "MS26H030049",
"cat": "探索项目",
"disc": "医学",
"lines": "细胞/类器官",
"ev": "细胞",
"amt26": 22.9,
"amt25": 14.76,
"ords26": 308,
"last_ship": "2040-04-09",
"act_n": 559,
"act_last": "2026-10-22",
"act90": 456,
"owner": "侯海瑜",
"score": 6,
"tier": "B",
"proj_score": 3,
"unit_score": 3,
"act": "确认课题组采购主体与预算年度；先寄试用装（项目：基于T细胞功能抑制的AI增效筛选模型发现溃疡性结）"
},
{
"no": 1053,
"unit": "浙江大学",
"pi": "李建平",
"name": "基于22q11.2微缺失综合征的SLC7A11调控溶酶体-线粒体协同功能障碍在精神分裂症发病机制中的作用研究",
"code": "MS26H090052",
"cat": "探索项目",
"disc": "医学",
"lines": "蛋白表达纯化",
"ev": "酶",
"amt26": 22.9,
"amt25": 14.76,
"ords26": 308,
"last_ship": "2040-04-09",
"act_n": 559,
"act_last": "2026-10-22",
"act90": 456,
"owner": "侯海瑜",
"score": 6,
"tier": "B",
"proj_score": 3,
"unit_score": 3,
"act": "确认课题组采购主体与预算年度；先寄试用装（项目：基于22q11.2微缺失综合征的SLC7A11调）"
},
{
"no": 1054,
"unit": "杭州师范大学",
"pi": "王大辉",
"name": "数字媒体使用对听力损失老年人社会联系衰退所致抑郁的代偿作用研究",
"code": "MS26H250003",
"cat": "探索项目",
"disc": "医学",
"lines": "未命中",
"ev": "",
"amt26": 1.1,
"amt25": 0.47,
"ords26": 48,
"last_ship": "2026-09-28",
"act_n": 105,
"act_last": "2026-09-28",
"act90": 86,
"owner": "侯海瑜",
"score": 4,
"tier": "C",
"proj_score": 2,
"unit_score": 2,
"act": "纳入单位级年度拜访清单，暂不单独立项（项目：数字媒体使用对听力损失老年人社会联系衰退所致抑郁）"
},
{
"no": 1057,
"unit": "浙江大学",
"pi": "闫伟",
"name": "TSP-1介导巨噬细胞花生四烯酸代谢促进脑出血后白质修复的机制探索",
"code": "MS26H090063",
"cat": "探索项目",
"disc": "医学",
"lines": "细胞/类器官",
"ev": "细胞",
"amt26": 22.9,
"amt25": 14.76,
"ords26": 308,
"last_ship": "2040-04-09",
"act_n": 559,
"act_last": "2026-10-22",
"act90": 456,
"owner": "侯海瑜",
"score": 6,
"tier": "B",
"proj_score": 3,
"unit_score": 3,
"act": "确认课题组采购主体与预算年度；先寄试用装（项目：TSP-1介导巨噬细胞花生四烯酸代谢促进脑出血后）"
},
{
"no": 1060,
"unit": "浙江中医药大学",
"pi": "韩冰",
"name": "二氢丹参酮I靶向剪接因子SRSF1抑制LncRNA SLC8A1-AS1的抗卵巢癌机制研究",
"code": "MS26H280022",
"cat": "探索项目",
"disc": "医学",
"lines": "未命中",
"ev": "",
"amt26": 0.55,
"amt25": 3.29,
"ords26": 46,
"last_ship": "2026-10-10",
"act_n": 107,
"act_last": "2026-10-20",
"act90": 88,
"owner": "叶信福",
"score": 3,
"tier": "C",
"proj_score": 2,
"unit_score": 1,
"act": "纳入单位级年度拜访清单，暂不单独立项（项目：二氢丹参酮I靶向剪接因子SRSF1抑制LncRN）"
},
{
"no": 1062,
"unit": "浙江大学",
"pi": "吴迪",
"name": "靶向调节性T细胞中拟素化E2耦联酶UBE2M的肿瘤免疫治疗新策略研究",
"code": "MS26H160140",
"cat": "探索项目",
"disc": "医学",
"lines": "蛋白表达纯化、细胞/类器官",
"ev": "细胞、酶",
"amt26": 22.9,
"amt25": 14.76,
"ords26": 308,
"last_ship": "2040-04-09",
"act_n": 559,
"act_last": "2026-10-22",
"act90": 456,
"owner": "侯海瑜",
"score": 7,
"tier": "A",
"proj_score": 4,
"unit_score": 3,
"act": "核对是否已建课题组档案；带 1–2 个同方向货号做技术交流（项目：靶向调节性T细胞中拟素化E2耦联酶UBE2M的肿）"
},
{
"no": 1063,
"unit": "杭州医学院",
"pi": "仇凤启",
"name": "靶向抑制LSD1维持过继性T细胞治疗实体瘤长效作用及机制研究",
"code": "MS26H160095",
"cat": "探索项目",
"disc": "医学",
"lines": "细胞/类器官",
"ev": "细胞",
"amt26": 0.04,
"amt25": 0.2,
"ords26": 9,
"last_ship": "2026-05-19",
"act_n": 4,
"act_last": "2026-09-20",
"act90": 4,
"owner": "侯海瑜",
"score": 4,
"tier": "C",
"proj_score": 3,
"unit_score": 1,
"act": "纳入单位级年度拜访清单，暂不单独立项（项目：靶向抑制LSD1维持过继性T细胞治疗实体瘤长效作）"
},
{
"no": 1064,
"unit": "浙江大学",
"pi": "吴蓉蓉",
"name": "GDF6通过ASCT1介导的丝氨酸转运调控心力衰竭后心脏收缩功能障碍的作用机制研究",
"code": "MS26H020034",
"cat": "探索项目",
"disc": "医学",
"lines": "未命中",
"ev": "",
"amt26": 22.9,
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"ords26": 308,
"last_ship": "2040-04-09",
"act_n": 559,
"act_last": "2026-10-22",
"act90": 456,
"owner": "侯海瑜",
"score": 5,
"tier": "B",
"proj_score": 2,
"unit_score": 3,
"act": "确认课题组采购主体与预算年度；先寄试用装（项目：GDF6通过ASCT1介导的丝氨酸转运调控心力衰）"
},
{
"no": 1065,
"unit": "浙江大学",
"pi": "南金良",
"name": "生物力学信号调控Prohibitin2介导心力衰竭线粒体嵴重塑与代谢失衡的机制研究",
"code": "MS26H020032",
"cat": "探索项目",
"disc": "医学",
"lines": "未命中",
"ev": "",
"amt26": 22.9,
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"last_ship": "2040-04-09",
"act_n": 559,
"act_last": "2026-10-22",
"act90": 456,
"owner": "侯海瑜",
"score": 5,
"tier": "B",
"proj_score": 2,
"unit_score": 3,
"act": "确认课题组采购主体与预算年度；先寄试用装（项目：生物力学信号调控Prohibitin2介导心力衰）"
},
{
"no": 1068,
"unit": "浙江大学",
"pi": "张子明",
"name": "SP1乳酸化修饰调控CDKN1A驱动支气管肺发育不良相关肺动脉高压内皮细胞功能障碍的机制研究",
"code": "MS26H040027",
"cat": "探索项目",
"disc": "医学",
"lines": "细胞/类器官",
"ev": "细胞",
"amt26": 22.9,
"amt25": 14.76,
"ords26": 308,
"last_ship": "2040-04-09",
"act_n": 559,
"act_last": "2026-10-22",
"act90": 456,
"owner": "侯海瑜",
"score": 6,
"tier": "B",
"proj_score": 3,
"unit_score": 3,
"act": "确认课题组采购主体与预算年度；先寄试用装（项目：SP1乳酸化修饰调控CDKN1A驱动支气管肺发育）"
},
{
"no": 1069,
"unit": "浙江大学",
"pi": "李梦轩",
"name": "RBM15通过m6A-IGF2BP2-PTHrP重塑骨微环境促进前列腺癌骨转移",
"code": "MS26H160137",
"cat": "探索项目",
"disc": "医学",
"lines": "未命中",
"ev": "",
"amt26": 22.9,
"amt25": 14.76,
"ords26": 308,
"last_ship": "2040-04-09",
"act_n": 559,
"act_last": "2026-10-22",
"act90": 456,
"owner": "侯海瑜",
"score": 5,
"tier": "B",
"proj_score": 2,
"unit_score": 3,
"act": "确认课题组采购主体与预算年度；先寄试用装（项目：RBM15通过m6A-IGF2BP2-PTHrP）"
},
{
"no": 1070,
"unit": "浙江大学",
"pi": "张望",
"name": "VI型分泌系统异戊二烯化修饰调控鲍曼不动杆菌巨噬细胞内适应性的机制研究",
"code": "MS26H190012",
"cat": "探索项目",
"disc": "医学",
"lines": "细胞/类器官",
"ev": "细胞",
"amt26": 22.9,
"amt25": 14.76,
"ords26": 308,
"last_ship": "2040-04-09",
"act_n": 559,
"act_last": "2026-10-22",
"act90": 456,
"owner": "侯海瑜",
"score": 6,
"tier": "B",
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"no": 1071,
"unit": "温州医科大学",
"pi": "林晓骥",
"name": "阿霉素清道夫提高乳腺癌放化疗疗效并降低心脏毒性的作用与机制研究",
"code": "MS26H220002",
"cat": "探索项目",
"disc": "医学",
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"no": 1072,
"unit": "浙江中医药大学",
"pi": "周佳",
"name": "腐胺介导肠-脑轴功能失调在昼夜节律紊乱加剧NPSLE中的作用和狼疮定干预机制",
"code": "MS26H290012",
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"no": 1073,
"unit": "浙江大学",
"pi": "熊炎",
"name": "晚期糖基化终产物清除系统促进糖尿病肩袖腱骨界面修复的机制研究",
"code": "MS26H060039",
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"act": "确认课题组采购主体与预算年度；先寄试用装（项目：晚期糖基化终产物清除系统促进糖尿病肩袖腱骨界面修）"
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{
"no": 1074,
"unit": "浙江大学",
"pi": "徐丽丽",
"name": "tRNA m7G修饰介导的EZH2翻译调控及其在七氟烷诱发新生鼠海马神经毒性染色质重塑过程中的作用和机制研究",
"code": "MS26H090056",
"cat": "探索项目",
"disc": "医学",
"lines": "未命中",
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"owner": "侯海瑜",
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"tier": "B",
"proj_score": 2,
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"act": "确认课题组采购主体与预算年度；先寄试用装（项目：tRNA m7G修饰介导的EZH2翻译调控及其在）"
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"no": 1075,
"unit": "杭州师范大学",
"pi": "王天卓",
"name": "KANK3突变在附壁样向实体样肺腺癌转化中的作用及机制研究",
"code": "MS26H160023",
"cat": "探索项目",
"disc": "医学",
"lines": "未命中",
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"owner": "侯海瑜",
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"tier": "C",
"proj_score": 2,
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"act": "纳入单位级年度拜访清单，暂不单独立项（项目：KANK3突变在附壁样向实体样肺腺癌转化中的作用）"
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"no": 1076,
"unit": "浙江中医药大学",
"pi": "祝萍",
"name": "术前MRI联合多模态数据解析局部进展期直肠癌肿瘤异质性并预测新辅助放化疗疗效及其失巢凋亡机制的探索研",
"code": "MS26H180023",
"cat": "探索项目",
"disc": "医学",
"lines": "未命中",
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"owner": "叶信福",
"score": 3,
"tier": "C",
"proj_score": 2,
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"act": "纳入单位级年度拜访清单，暂不单独立项（项目：术前MRI联合多模态数据解析局部进展期直肠癌肿瘤）"
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"no": 1077,
"unit": "浙江中医药大学",
"pi": "蒋永亮",
"name": "究DNMT3a调控背根神经节GABAA受体基因启动子甲基化在根性痛中的作用与电针的干预机制",
"code": "MS26H270018",
"cat": "探索项目",
"disc": "医学",
"lines": "未命中",
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"tier": "C",
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"act": "纳入单位级年度拜访清单，暂不单独立项（项目：究DNMT3a调控背根神经节GABAA受体基因启）"
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"no": 1078,
"unit": "浙江大学",
"pi": "蒋沛月",
"name": "转录因子JUNB调控巨噬细胞免疫失衡致子痫前期胎盘功能障碍的机制研究",
"code": "MS26H040028",
"cat": "探索项目",
"disc": "医学",
"lines": "细胞/类器官",
"ev": "细胞",
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"act_n": 559,
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"owner": "侯海瑜",
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"tier": "B",
"proj_score": 3,
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"act": "确认课题组采购主体与预算年度；先寄试用装（项目：转录因子JUNB调控巨噬细胞免疫失衡致子痫前期胎）"
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"no": 1079,
"unit": "温州医科大学",
"pi": "张雷",
"name": "TL-E7生物陶瓷介导ATF4乳酸化促进骨质疏松性骨缺损修复的基础研究",
"code": "MS26H060013",
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"act_last": "2026-10-22",
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"owner": "袁殿果",
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"tier": "C",
"proj_score": 2,
"unit_score": 2,
"act": "纳入单位级年度拜访清单，暂不单独立项（项目：TL-E7生物陶瓷介导ATF4乳酸化促进骨质疏松）"
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{
"no": 1080,
"unit": "浙江大学",
"pi": "揭志伟",
"name": "NAE1介导ACSL3拟素化修饰调控破骨细胞铁代谢在骨质疏松中的作用及机制",
"code": "MS26H070022",
"cat": "探索项目",
"disc": "医学",
"lines": "细胞/类器官",
"ev": "细胞",
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"act_n": 559,
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"owner": "侯海瑜",
"score": 6,
"tier": "B",
"proj_score": 3,
"unit_score": 3,
"act": "确认课题组采购主体与预算年度；先寄试用装（项目：NAE1介导ACSL3拟素化修饰调控破骨细胞铁代）"
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{
"no": 1082,
"unit": "杭州医学院",
"pi": "朱骁拯",
"name": "HIF-1α抑制ACSL4调节脂质代谢稳态赋予未分化甲状腺癌铁死亡抵抗性的机制研究",
"code": "MS26H070016",
"cat": "探索项目",
"disc": "医学",
"lines": "未命中",
"ev": "",
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"act_n": 4,
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"owner": "侯海瑜",
"score": 3,
"tier": "C",
"proj_score": 2,
"unit_score": 1,
"act": "纳入单位级年度拜访清单，暂不单独立项（项目：HIF-1α抑制ACSL4调节脂质代谢稳态赋予未）"
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{
"no": 1084,
"unit": "温州医科大学",
"pi": "姜丹",
"name": "基于代谢-免疫串扰的HK2-MAVS轴靶向干预单纯疱疹性角膜炎的新策略研究",
"code": "MS26H120003",
"cat": "探索项目",
"disc": "医学",
"lines": "未命中",
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"act_last": "2026-10-22",
"act90": 236,
"owner": "袁殿果",
"score": 4,
"tier": "C",
"proj_score": 2,
"unit_score": 2,
"act": "纳入单位级年度拜访清单，暂不单独立项（项目：基于代谢-免疫串扰的HK2-MAVS轴靶向干预单）"
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{
"no": 1085,
"unit": "浙江大学",
"pi": "赵迪",
"name": "颏舌肌电-机械协同失调及其在阻塞性睡眠呼吸暂停气道塌陷形成中的作用机制研究",
"code": "MS26H130005",
"cat": "探索项目",
"disc": "医学",
"lines": "未命中",
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"owner": "侯海瑜",
"score": 5,
"tier": "B",
"proj_score": 2,
"unit_score": 3,
"act": "确认课题组采购主体与预算年度；先寄试用装（项目：颏舌肌电-机械协同失调及其在阻塞性睡眠呼吸暂停气）"
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{
"no": 1086,
"unit": "杭州师范大学",
"pi": "朱晓静",
"name": "Mettl16通过m6A甲基化修饰调控Runx2水平促进小鼠上腭发育的机制研究",
"code": "MS26H140001",
"cat": "探索项目",
"disc": "医学",
"lines": "未命中",
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"owner": "侯海瑜",
"score": 4,
"tier": "C",
"proj_score": 2,
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"act": "纳入单位级年度拜访清单，暂不单独立项（项目：Mettl16通过m6A甲基化修饰调控Runx2）"
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{
"no": 1087,
"unit": "浙江大学",
"pi": "张霞",
"name": "脱落乳牙干细胞经SHP2去磷酸化修饰外周神经元中TRPV1缓解三叉神经痛的机制研究",
"code": "MS26H140013",
"cat": "探索项目",
"disc": "医学",
"lines": "细胞/类器官",
"ev": "干细胞、细胞",
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"act_last": "2026-10-22",
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"owner": "侯海瑜",
"score": 6,
"tier": "B",
"proj_score": 3,
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"act": "确认课题组采购主体与预算年度；先寄试用装（项目：脱落乳牙干细胞经SHP2去磷酸化修饰外周神经元中）"
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{
"no": 1089,
"unit": "杭州师范大学",
"pi": "姜远远",
"name": "星形胶质细胞YAP通过DHRS3信号抑制胶质母细胞瘤进展的作用与机制研究",
"code": "MS26H160025",
"cat": "探索项目",
"disc": "医学",
"lines": "细胞/类器官",
"ev": "细胞",
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"owner": "侯海瑜",
"score": 5,
"tier": "B",
"proj_score": 3,
"unit_score": 2,
"act": "确认课题组采购主体与预算年度；先寄试用装（项目：星形胶质细胞YAP通过DHRS3信号抑制胶质母细）"
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{
"no": 1091,
"unit": "浙江中医药大学",
"pi": "郭静妍",
"name": "Drp1-Parkin轴调控线粒体代谢重编程探讨白术多糖抑制肌肉衰老的作用机制",
"code": "MS26H280032",
"cat": "探索项目",
"disc": "医学",
"lines": "未命中",
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"act90": 88,
"owner": "叶信福",
"score": 3,
"tier": "C",
"proj_score": 2,
"unit_score": 1,
"act": "纳入单位级年度拜访清单，暂不单独立项（项目：Drp1-Parkin轴调控线粒体代谢重编程探讨）"
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{
"no": 1093,
"unit": "国科大杭州高等研究院",
"pi": "李亚洲",
"name": "非拟肽类新型肽酶神经溶素激活剂的发现及抗抑郁活性研究",
"code": "MS26H300004",
"cat": "探索项目",
"disc": "医学",
"lines": "蛋白表达纯化",
"ev": "酶",
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"act_n": 89,
"act_last": "2026-10-21",
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"owner": "袁殿果",
"score": 4,
"tier": "C",
"proj_score": 3,
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"act": "纳入单位级年度拜访清单，暂不单独立项（项目：非拟肽类新型肽酶神经溶素激活剂的发现及抗抑郁活性）"
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{
"no": 1094,
"unit": "浙江大学",
"pi": "刘迎强",
"name": "CDK12磷酸化驱动的转录重编程在结直肠癌KRAS G12C抑制剂耐药中的作用机制及靶向治疗研究",
"code": "MS26H310031",
"cat": "探索项目",
"disc": "医学",
"lines": "未命中",
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"act_last": "2026-10-22",
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"owner": "侯海瑜",
"score": 5,
"tier": "B",
"proj_score": 2,
"unit_score": 3,
"act": "确认课题组采购主体与预算年度；先寄试用装（项目：CDK12磷酸化驱动的转录重编程在结直肠癌KRA）"
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{
"no": 1096,
"unit": "温州医科大学",
"pi": "程谷",
"name": "联合抗炎、促血管形成、促骨再生策略构建ROS响应型“子-母”载药微球治疗ORNJ术后骨缺损的实验机制研究",
"code": "MS26H140002",
"cat": "探索项目",
"disc": "医学",
"lines": "未命中",
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"act90": 236,
"owner": "袁殿果",
"score": 4,
"tier": "C",
"proj_score": 2,
"unit_score": 2,
"act": "纳入单位级年度拜访清单，暂不单独立项（项目：联合抗炎、促血管形成、促骨再生策略构建ROS响应）"
},
{
"no": 1097,
"unit": "温州医科大学",
"pi": "桑晓琳",
"name": "SGK1-NRF2信号轴抑制铁死亡的作用机制及其在靶向治疗卵巢癌中的应用潜力研究",
"code": "MS26H160032",
"cat": "探索项目",
"disc": "医学",
"lines": "未命中",
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"act_last": "2026-10-22",
"act90": 236,
"owner": "袁殿果",
"score": 4,
"tier": "C",
"proj_score": 2,
"unit_score": 2,
"act": "纳入单位级年度拜访清单，暂不单独立项（项目：SGK1-NRF2信号轴抑制铁死亡的作用机制及其）"
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{
"no": 1098,
"unit": "浙江大学",
"pi": "王潇",
"name": "基于R-loop结构的SPOP泛素化修饰METTL3调控同源重组修复在前列腺癌进展中的作用及分子机制研究",
"code": "MS26H160113",
"cat": "探索项目",
"disc": "医学",
"lines": "分子克隆",
"ev": "同源重组",
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"last_ship": "2040-04-09",
"act_n": 559,
"act_last": "2026-10-22",
"act90": 456,
"owner": "侯海瑜",
"score": 6,
"tier": "B",
"proj_score": 3,
"unit_score": 3,
"act": "确认课题组采购主体与预算年度；先寄试用装（项目：基于R-loop结构的SPOP泛素化修饰METT）"
},
{
"no": 1099,
"unit": "杭州师范大学",
"pi": "徐勇昌",
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"code": "MS26H190005",
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"pi": "赵炎波",
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"unit": "浙江大学",
"pi": "张忻",
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"pi": "阳筱甜",
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"pi": "张添源",
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"no": 1118,
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"pi": "朱美飞",
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"unit": "浙江中医药大学",
"pi": "邵科钉",
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"no": 1121,
"unit": "浙江大学",
"pi": "冯洁惠",
"name": "基于多模态心电数据的院内心源性猝死动态风险评估及早期预警模型研究",
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"pi": "陈浩田",
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"pi": "沈婷",
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"pi": "林金",
"name": "微环境响应微针贴片通过催化ROS清除及调控ACOX1/PPARα通路改善银屑病样炎症的机制研究",
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"unit": "浙江大学",
"pi": "郑行",
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"unit": "浙江理工大学",
"pi": "秦楚",
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"unit": "浙江理工大学",
"pi": "曹军",
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"pi": "陈姣姣",
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"pi": "王廷",
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"pi": "孙玥",
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"unit": "浙江工商大学",
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"no": 1910,
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"pi": "边玉靖",
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"no": 1913,
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"no": 1918,
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"no": 1921,
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"no": 1947,
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"no": 1959,
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"pi": "史晨",
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"pi": "董丽娜",
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"no": 1974,
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"pi": "王飞艳",
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"pi": "王凌天",
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"no": 1981,
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"no": 1982,
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"no": 1983,
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"pi": "陆斌",
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"no": 1984,
"unit": "浙江大学",
"pi": "周锦仁",
"name": "骨化三醇调控巨噬细胞活化招募Treg在代谢功能障碍相关脂肪性肝炎中的作用机制研究",
"code": "QN26H030049",
"cat": "青基项目",
"disc": "医学",
"lines": "细胞/类器官",
"ev": "细胞",
"amt26": 22.9,
"amt25": 14.76,
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"last_ship": "2040-04-09",
"act_n": 559,
"act_last": "2026-10-22",
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"owner": "侯海瑜",
"score": 5,
"tier": "B",
"proj_score": 2,
"unit_score": 3,
"act": "确认课题组采购主体与预算年度；先寄试用装（项目：骨化三醇调控巨噬细胞活化招募Treg在代谢功能障）"
},
{
"no": 1985,
"unit": "浙江大学",
"pi": "潮昀琦",
"name": "靶向SNORD116缺失诱导的mtDAMP：解析Prader-Willi综合征脂肪组织源性代谢性炎症的分子密码",
"code": "QN26H070007",
"cat": "青基项目",
"disc": "医学",
"lines": "未命中",
"ev": "",
"amt26": 22.9,
"amt25": 14.76,
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"last_ship": "2040-04-09",
"act_n": 559,
"act_last": "2026-10-22",
"act90": 456,
"owner": "侯海瑜",
"score": 4,
"tier": "C",
"proj_score": 1,
"unit_score": 3,
"act": "纳入单位级年度拜访清单，暂不单独立项（项目：靶向SNORD116缺失诱导的mtDAMP：解析）"
},
{
"no": 1986,
"unit": "浙江大学",
"pi": "林瑶",
"name": "RVG29和血小板膜修饰的伪线粒体应用于单宁酸与辛酸共载级联靶向递送治疗脓毒症脑病",
"code": "QN26H150021",
"cat": "青基项目",
"disc": "医学",
"lines": "mRNA/核酸药",
"ev": "递送",
"amt26": 22.9,
"amt25": 14.76,
"ords26": 308,
"last_ship": "2040-04-09",
"act_n": 559,
"act_last": "2026-10-22",
"act90": 456,
"owner": "侯海瑜",
"score": 5,
"tier": "B",
"proj_score": 2,
"unit_score": 3,
"act": "确认课题组采购主体与预算年度；先寄试用装（项目：RVG29和血小板膜修饰的伪线粒体应用于单宁酸与）"
},
{
"no": 1987,
"unit": "浙江大学",
"pi": "陈亮",
"name": "基于噬菌体免疫靶标修饰技术的骨感染治疗体系构建与应用研究",
"code": "QN26H060027",
"cat": "青基项目",
"disc": "医学",
"lines": "未命中",
"ev": "",
"amt26": 22.9,
"amt25": 14.76,
"ords26": 308,
"last_ship": "2040-04-09",
"act_n": 559,
"act_last": "2026-10-22",
"act90": 456,
"owner": "侯海瑜",
"score": 4,
"tier": "C",
"proj_score": 1,
"unit_score": 3,
"act": "纳入单位级年度拜访清单，暂不单独立项（项目：基于噬菌体免疫靶标修饰技术的骨感染治疗体系构建与）"
},
{
"no": 1988,
"unit": "浙江大学",
"pi": "张淑霞",
"name": "外侧隔核GABA能神经元内Tau通过Fyn促进GluN2B和PSD95结合进而调控突触功能介导慢性疼痛焦虑共病的机制研",
"code": "QN26H090050",
"cat": "青基项目",
"disc": "医学",
"lines": "未命中",
"ev": "",
"amt26": 22.9,
"amt25": 14.76,
"ords26": 308,
"last_ship": "2040-04-09",
"act_n": 559,
"act_last": "2026-10-22",
"act90": 456,
"owner": "侯海瑜",
"score": 4,
"tier": "C",
"proj_score": 1,
"unit_score": 3,
"act": "纳入单位级年度拜访清单，暂不单独立项（项目：外侧隔核GABA能神经元内Tau通过Fyn促进G）"
},
{
"no": 1989,
"unit": "杭州师范大学",
"pi": "孙芬",
"name": "究基于空间组学的α7nAChR/CAMKII-SynGAP轴调控卒中突触再生机制研究",
"code": "QN26H090007",
"cat": "青基项目",
"disc": "医学",
"lines": "未命中",
"ev": "",
"amt26": 1.1,
"amt25": 0.47,
"ords26": 48,
"last_ship": "2026-09-28",
"act_n": 105,
"act_last": "2026-09-28",
"act90": 86,
"owner": "侯海瑜",
"score": 3,
"tier": "C",
"proj_score": 1,
"unit_score": 2,
"act": "纳入单位级年度拜访清单，暂不单独立项（项目：究基于空间组学的α7nAChR/CAMKII-S）"
},
{
"no": 1990,
"unit": "温州医科大学",
"pi": "邢彦超",
"name": "基于药物非临床安全性评估“去动物化”新方法（NAMs）探讨黄芪调控肠道CYP3A4介导的药物相互作用",
"code": "QN26H290004",
"cat": "青基项目",
"disc": "医学",
"lines": "未命中",
"ev": "",
"amt26": 2.15,
"amt25": 2.95,
"ords26": 73,
"last_ship": "2026-10-21",
"act_n": 262,
"act_last": "2026-10-22",
"act90": 236,
"owner": "袁殿果",
"score": 3,
"tier": "C",
"proj_score": 1,
"unit_score": 2,
"act": "纳入单位级年度拜访清单，暂不单独立项（项目：基于药物非临床安全性评估“去动物化”新方法（NA）"
},
{
"no": 1991,
"unit": "杭州医学院",
"pi": "陆益超",
"name": "构建重塑瘤内淋巴样结构的控释系统以提高过继T细胞浸润介导的实体瘤杀伤及机制研究",
"code": "QN26H300019",
"cat": "青基项目",
"disc": "医学",
"lines": "细胞/类器官",
"ev": "细胞",
"amt26": 0.04,
"amt25": 0.2,
"ords26": 9,
"last_ship": "2026-05-19",
"act_n": 4,
"act_last": "2026-09-20",
"act90": 4,
"owner": "侯海瑜",
"score": 3,
"tier": "C",
"proj_score": 2,
"unit_score": 1,
"act": "纳入单位级年度拜访清单，暂不单独立项（项目：构建重塑瘤内淋巴样结构的控释系统以提高过继T细胞）"
},
{
"no": 1992,
"unit": "浙江大学",
"pi": "蒋诗漫",
"name": "枯草芽孢杆菌孢子靶向递送Amuc_1100蛋白（BS-Spore@Amuc_1100）通过介导Wnt/β-Catenin-Th17轴改",
"code": "QN26H030041",
"cat": "青基项目",
"disc": "医学",
"lines": "蛋白表达纯化、mRNA/核酸药",
"ev": "蛋白、递送",
"amt26": 22.9,
"amt25": 14.76,
"ords26": 308,
"last_ship": "2040-04-09",
"act_n": 559,
"act_last": "2026-10-22",
"act90": 456,
"owner": "侯海瑜",
"score": 6,
"tier": "B",
"proj_score": 3,
"unit_score": 3,
"act": "确认课题组采购主体与预算年度；先寄试用装（项目：枯草芽孢杆菌孢子靶向递送Amuc_1100蛋白（）"
},
{
"no": 1993,
"unit": "温州医科大学",
"pi": "曾未良",
"name": "善葡聚糖硫酸钠诱导的结肠炎尾管蛋白gp11和gp12变异驱动噬菌体宿主谱拓宽的作用与机制研究",
"code": "QN26H200001",
"cat": "青基项目",
"disc": "医学",
"lines": "蛋白表达纯化",
"ev": "蛋白",
"amt26": 2.15,
"amt25": 2.95,
"ords26": 73,
"last_ship": "2026-10-21",
"act_n": 262,
"act_last": "2026-10-22",
"act90": 236,
"owner": "袁殿果",
"score": 4,
"tier": "C",
"proj_score": 2,
"unit_score": 2,
"act": "纳入单位级年度拜访清单，暂不单独立项（项目：善葡聚糖硫酸钠诱导的结肠炎尾管蛋白gp11和gp）"
},
{
"no": 1994,
"unit": "浙江中医药大学",
"pi": "李小艳",
"name": "山奈酚“肠肠循环”促肠道“粪副拟杆菌-胆汁酸”代谢轴重塑Th17/Treg平衡抑制溃疡性结肠炎的机制",
"code": "QN26H280019",
"cat": "青基项目",
"disc": "医学",
"lines": "未命中",
"ev": "",
"amt26": 0.55,
"amt25": 3.29,
"ords26": 46,
"last_ship": "2026-10-10",
"act_n": 107,
"act_last": "2026-10-20",
"act90": 88,
"owner": "叶信福",
"score": 2,
"tier": "C",
"proj_score": 1,
"unit_score": 1,
"act": "纳入单位级年度拜访清单，暂不单独立项（项目：山奈酚“肠肠循环”促肠道“粪副拟杆菌-胆汁酸”代）"
},
{
"no": 1995,
"unit": "浙江大学",
"pi": "孟雨婷",
"name": "脆弱拟杆菌通过入胞方式调控PKM2二聚化诱导肝癌细胞干性维持的作用机制研究",
"code": "QN26H160090",
"cat": "青基项目",
"disc": "医学",
"lines": "细胞/类器官",
"ev": "细胞",
"amt26": 22.9,
"amt25": 14.76,
"ords26": 308,
"last_ship": "2040-04-09",
"act_n": 559,
"act_last": "2026-10-22",
"act90": 456,
"owner": "侯海瑜",
"score": 5,
"tier": "B",
"proj_score": 2,
"unit_score": 3,
"act": "确认课题组采购主体与预算年度；先寄试用装（项目：脆弱拟杆菌通过入胞方式调控PKM2二聚化诱导肝癌）"
},
{
"no": 1996,
"unit": "浙江大学",
"pi": "朱星鑫",
"name": "受DNA甲基化调控的TIPIN蛋白通过调控EGFR泛素化降解促进肝癌进展的机制研究",
"code": "QN26H160078",
"cat": "青基项目",
"disc": "医学",
"lines": "蛋白表达纯化",
"ev": "蛋白",
"amt26": 22.9,
"amt25": 14.76,
"ords26": 308,
"last_ship": "2040-04-09",
"act_n": 559,
"act_last": "2026-10-22",
"act90": 456,
"owner": "侯海瑜",
"score": 5,
"tier": "B",
"proj_score": 2,
"unit_score": 3,
"act": "确认课题组采购主体与预算年度；先寄试用装（项目：受DNA甲基化调控的TIPIN蛋白通过调控EGF）"
},
{
"no": 1997,
"unit": "浙江中医药大学",
"pi": "盛璇",
"name": "可溶性TREM2促进小胶质细胞mTOR依赖的葡萄糖代谢缓解阿尔茨海默病的机制研究",
"code": "QN26H310010",
"cat": "青基项目",
"disc": "医学",
"lines": "细胞/类器官",
"ev": "细胞",
"amt26": 0.55,
"amt25": 3.29,
"ords26": 46,
"last_ship": "2026-10-10",
"act_n": 107,
"act_last": "2026-10-20",
"act90": 88,
"owner": "叶信福",
"score": 3,
"tier": "C",
"proj_score": 2,
"unit_score": 1,
"act": "纳入单位级年度拜访清单，暂不单独立项（项目：可溶性TREM2促进小胶质细胞mTOR依赖的葡萄）"
},
{
"no": 1998,
"unit": "浙江大学",
"pi": "孙泳",
"name": "生命早期二氧化钛暴露通过重塑肠道菌群和Treg细胞组蛋白修饰增加溃疡性结肠炎易感性的机制研究",
"code": "QN26H030050",
"cat": "青基项目",
"disc": "医学",
"lines": "蛋白表达纯化、细胞/类器官",
"ev": "细胞、蛋白",
"amt26": 22.9,
"amt25": 14.76,
"ords26": 308,
"last_ship": "2040-04-09",
"act_n": 559,
"act_last": "2026-10-22",
"act90": 456,
"owner": "侯海瑜",
"score": 6,
"tier": "B",
"proj_score": 3,
"unit_score": 3,
"act": "确认课题组采购主体与预算年度；先寄试用装（项目：生命早期二氧化钛暴露通过重塑肠道菌群和Treg细）"
},
{
"no": 2001,
"unit": "浙江大学",
"pi": "丁理峰",
"name": "piR-PCa 介导 HADHA 去乙酰化促进 HADHA/HADHB 互作调控前列腺癌脂肪酸氧化及恶性进展的机制研究",
"code": "QN26H160079",
"cat": "青基项目",
"disc": "医学",
"lines": "未命中",
"ev": "",
"amt26": 22.9,
"amt25": 14.76,
"ords26": 308,
"last_ship": "2040-04-09",
"act_n": 559,
"act_last": "2026-10-22",
"act90": 456,
"owner": "侯海瑜",
"score": 4,
"tier": "C",
"proj_score": 1,
"unit_score": 3,
"act": "纳入单位级年度拜访清单，暂不单独立项（项目：piR-PCa 介导 HADHA 去乙酰化促进 ）"
},
{
"no": 2002,
"unit": "浙江中医药大学",
"pi": "范梦强",
"name": "骨健口服液通过IL-1β/c-Jun-MMP13逆转干细胞焦亡干预膝骨关节炎的作用机制研究",
"code": "QN26H270019",
"cat": "青基项目",
"disc": "医学",
"lines": "细胞/类器官",
"ev": "干细胞、细胞",
"amt26": 0.55,
"amt25": 3.29,
"ords26": 46,
"last_ship": "2026-10-10",
"act_n": 107,
"act_last": "2026-10-20",
"act90": 88,
"owner": "叶信福",
"score": 3,
"tier": "C",
"proj_score": 2,
"unit_score": 1,
"act": "纳入单位级年度拜访清单，暂不单独立项（项目：骨健口服液通过IL-1β/c-Jun-MMP13）"
},
{
"no": 2004,
"unit": "浙江大学",
"pi": "孟凡兵",
"name": "神经元组蛋白H3K9乳酸化促进Ralbp1表达引起线粒体分裂增加介导术后认知功能障碍",
"code": "QN26H090051",
"cat": "青基项目",
"disc": "医学",
"lines": "蛋白表达纯化",
"ev": "蛋白",
"amt26": 22.9,
"amt25": 14.76,
"ords26": 308,
"last_ship": "2040-04-09",
"act_n": 559,
"act_last": "2026-10-22",
"act90": 456,
"owner": "侯海瑜",
"score": 5,
"tier": "B",
"proj_score": 2,
"unit_score": 3,
"act": "确认课题组采购主体与预算年度；先寄试用装（项目：神经元组蛋白H3K9乳酸化促进Ralbp1表达引）"
},
{
"no": 2005,
"unit": "温州医科大学",
"pi": "郭祥雨",
"name": "基于视觉引导的视网膜微创手术机器人导航方法研究",
"code": "QN26H120013",
"cat": "青基项目",
"disc": "医学",
"lines": "未命中",
"ev": "",
"amt26": 2.15,
"amt25": 2.95,
"ords26": 73,
"last_ship": "2026-10-21",
"act_n": 262,
"act_last": "2026-10-22",
"act90": 236,
"owner": "袁殿果",
"score": 3,
"tier": "C",
"proj_score": 1,
"unit_score": 2,
"act": "纳入单位级年度拜访清单，暂不单独立项（项目：基于视觉引导的视网膜微创手术机器人导航方法研究）"
},
{
"no": 2006,
"unit": "浙江大学",
"pi": "杨玉婷",
"name": "纳米酶复合抗菌水凝胶调控铁代谢氧化应激稳态治疗牙周炎中牙槽骨破坏的作用机制研究",
"code": "QN26H140023",
"cat": "青基项目",
"disc": "医学",
"lines": "蛋白表达纯化",
"ev": "酶",
"amt26": 22.9,
"amt25": 14.76,
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"last_ship": "2040-04-09",
"act_n": 559,
"act_last": "2026-10-22",
"act90": 456,
"owner": "侯海瑜",
"score": 5,
"tier": "B",
"proj_score": 2,
"unit_score": 3,
"act": "确认课题组采购主体与预算年度；先寄试用装（项目：纳米酶复合抗菌水凝胶调控铁代谢氧化应激稳态治疗牙）"
},
{
"no": 2007,
"unit": "浙江中医药大学",
"pi": "傅宏阳",
"name": "基于双载药靶向纳米粒微针激活AMPK-Nrf2通路的银屑病血热证治疗机制研究",
"code": "QN26H270016",
"cat": "青基项目",
"disc": "医学",
"lines": "未命中",
"ev": "",
"amt26": 0.55,
"amt25": 3.29,
"ords26": 46,
"last_ship": "2026-10-10",
"act_n": 107,
"act_last": "2026-10-20",
"act90": 88,
"owner": "叶信福",
"score": 2,
"tier": "C",
"proj_score": 1,
"unit_score": 1,
"act": "纳入单位级年度拜访清单，暂不单独立项（项目：基于双载药靶向纳米粒微针激活AMPK-Nrf2通）"
},
{
"no": 2008,
"unit": "浙江中医药大学",
"pi": "徐锋",
"name": "芩榆清肠方调控生孢梭菌介导吲哚-3-丙酸代谢促进溃疡性结肠炎肠黏膜屏障修复的机制研究",
"code": "QN26H270013",
"cat": "青基项目",
"disc": "医学",
"lines": "未命中",
"ev": "",
"amt26": 0.55,
"amt25": 3.29,
"ords26": 46,
"last_ship": "2026-10-10",
"act_n": 107,
"act_last": "2026-10-20",
"act90": 88,
"owner": "叶信福",
"score": 2,
"tier": "C",
"proj_score": 1,
"unit_score": 1,
"act": "纳入单位级年度拜访清单，暂不单独立项（项目：芩榆清肠方调控生孢梭菌介导吲哚-3-丙酸代谢促进）"
},
{
"no": 2009,
"unit": "浙江大学",
"pi": "陈漳",
"name": "靶向MAT2A/PD-1代谢免疫调控轴促进移植物抗原反应性T细胞耗竭及诱导心脏移植物长期存活的机制研究",
"code": "QN26H100010",
"cat": "青基项目",
"disc": "医学",
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"no": 2010,
"unit": "杭州医学院",
"pi": "钱俊杰",
"name": "阻断TIM-3对纳秒脉冲电场消融介导的抗肿瘤免疫反应的影响及其机制",
"code": "QN26H160075",
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{
"no": 2012,
"unit": "浙江农林大学",
"pi": "江志彦",
"name": "ThMYB14介导黄酮合成调节根际微环境提高三叶青根腐病抗性的分子机制",
"code": "QN26H280005",
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{
"no": 2013,
"unit": "温州医科大学",
"pi": "朱姗",
"name": "千层纸素A靶向LCN2-铁稳态轴延缓皮肤衰老的分子机制研究",
"code": "QN26H280011",
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"no": 2014,
"unit": "浙江大学",
"pi": "陈佳娴",
"name": "靶向血清素受体HTR1b改善胆管树再生促进可移植类肝器官构建研究",
"code": "QN26H030047",
"cat": "青基项目",
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{
"no": 2018,
"unit": "浙江中医药大学",
"pi": "陶嘉茵",
"name": "基于lncRNA PVT1/SET7/CD36表观遗传网络探讨清热消癥方干预糖尿病肾脏疾病脂质自噬的机制研究",
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"cat": "青基项目",
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{
"no": 2019,
"unit": "浙江中医药大学",
"pi": "郭阳",
"name": "脂质液晶相变调控黄芩苷/甘草酸协同递送体系的构建及其干预急性酒精性肝损伤机制研究",
"code": "QN26H290021",
"cat": "青基项目",
"disc": "医学",
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"act": "纳入单位级年度拜访清单，暂不单独立项（项目：脂质液晶相变调控黄芩苷/甘草酸协同递送体系的构建）"
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{
"no": 2021,
"unit": "浙江中医药大学",
"pi": "高思琦",
"name": "桑黄多糖调控SIRT1介导p53脱乙酰化抑制肝细胞铁死亡的抗肝纤维化效应及机制",
"code": "QN26H280024",
"cat": "青基项目",
"disc": "医学",
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"no": 2022,
"unit": "温州医科大学",
"pi": "高爽",
"name": "菜蓟苦素通过靶向IL-33/ST2轴治疗银屑病的作用及机制研究",
"code": "QN26H310005",
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{
"no": 2023,
"unit": "浙江大学",
"pi": "王凯",
"name": "Clec4d通过激活心肌细胞中Mdm2/NF-κB通路介导心脏缺血再灌注损伤的机制研究",
"code": "QN26H020021",
"cat": "青基项目",
"disc": "医学",
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{
"no": 2024,
"unit": "温州医科大学",
"pi": "梁倩",
"name": "FABP5通过mTORC1-自噬轴调控BACE1降解在阿尔茨海默病中的作用机制研究",
"code": "QN26H090014",
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"no": 2026,
"unit": "杭州师范大学",
"pi": "冯博孩",
"name": "基于膨胀注意力特征融合的HPV阴性头颈部鳞癌病理风险微环境识别及决策机制研究",
"code": "QN26H160006",
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"no": 2027,
"unit": "温州医科大学",
"pi": "史钰",
"name": "UL38介导内质网应激驱动脂滴生物合成促进巨细胞病毒复制的功能与机制研究",
"code": "QN26H190009",
"cat": "青基项目",
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"no": 2028,
"unit": "浙江大学",
"pi": "LIU HENGJIA",
"name": "补体C3调控髓源性抑制细胞促进结节性硬化症肾肿瘤进展机制研究",
"code": "QN26H160129",
"cat": "青基项目",
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"no": 2029,
"unit": "浙江大学",
"pi": "刘汉超",
"name": "抑制PMSC的IL-1β耐受提高其对CP/CPPS的治疗作用及机制研究",
"code": "QN26H040017",
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{
"no": 2030,
"unit": "浙江大学",
"pi": "张玉军",
"name": "PD-L1偶联单原子纳米酶的Nano-ADC药物构建及增强前列腺癌免疫治疗机制",
"code": "QN26H160098",
"cat": "青基项目",
"disc": "医学",
"lines": "蛋白表达纯化",
"ev": "酶",
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"no": 2031,
"unit": "浙江大学",
"pi": "孙秀娜",
"name": "基于知识蒸馏与mNGS/WGS多源数据融合的结核分支杆菌的耐药性预测研究",
"code": "QN26H300020",
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"no": 2033,
"unit": "浙江大学",
"pi": "陈晓霞",
"name": "基于DNA折纸构建智能转录纳米工厂精准诱导肿瘤细胞焦亡用于肝细胞癌治疗",
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"no": 2034,
"unit": "浙江大学",
"pi": "张俊磊",
"name": "空间多组学解析HERV-K113病毒对小儿胆道闭锁发生发展的影响及机制",
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"no": 2035,
"unit": "浙江大学",
"pi": "周凌辉",
"name": "CXCR3/CXCL9轴介导的CAR-T细胞肿瘤定向趋化及活化增强机制研究",
"code": "QN26H080011",
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"no": 2036,
"unit": "浙江大学",
"pi": "何放",
"name": "负载相变脂质体水凝胶系统协同调控HIF-1α促进糖尿病创面愈合的研究",
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"unit": "杭州医学院",
"pi": "裘航远",
"name": "分子伴侣蛋白HSC70 在MYBPC3 突变相关肥厚性心肌病中的作用和机制研究",
"code": "QN26H020019",
"cat": "青基项目",
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{
"no": 2038,
"unit": "浙江大学",
"pi": "张婷",
"name": "人类内源性逆转录病毒K102 Env-TM通过TCR/CD3ε诱导T细胞异常促进SLE进展的机制研究及干预策略",
"code": "QN26H100013",
"cat": "青基项目",
"disc": "医学",
"lines": "细胞/类器官",
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"unit": "浙江大学",
"pi": "陈超露",
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"pi": "汪芾",
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"pi": "沈冬妮",
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"unit": "浙江大学",
"pi": "曾祥钧",
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"unit": "浙江大学",
"pi": "施归鸿",
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"unit": "浙江大学",
"pi": "裘卓琼",
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"code": "QN26H110012",
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"no": 2059,
"unit": "浙江大学",
"pi": "孙佳斐",
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"unit": "温州医科大学",
"pi": "金辞量",
"name": "IFN-γ-NR4A1轴通过调控血管内皮功能影响免疫性胆管炎局部T细胞免疫浸润的机制研究",
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"no": 2067,
"unit": "浙江大学",
"pi": "郭珊珊",
"name": "CBLB–CSF2信号轴介导的功能抑制及其靶向干预在增强CD19 CAR-NK抗B细胞淋巴瘤效能中的作用",
"code": "QN26H080013",
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"pi": "唐涛",
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"pi": "薄志远",
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"pi": "刘兴阳",
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"unit": "浙江大学",
"pi": "黄杨宇鑫",
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"unit": "浙江大学",
"pi": "姚汉涛",
"name": "巨噬细胞丝氨酸穿梭挽救牙骨质损伤的机制研究",
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"unit": "浙江大学",
"pi": "潘金花",
"name": "基于血管时空异质性的肝癌不可逆电穿孔术后复发预警模型构建与验证",
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"pi": "黄慧颖",
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"unit": "浙江大学",
"pi": "龚哲",
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"unit": "浙江大学",
"pi": "鲁智敏",
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"no": 2085,
"unit": "浙江大学",
"pi": "天骄",
"name": "CXCL14-CXCR4信号介导内膜间质细胞与巨噬细胞互作异常导致子宫腺肌症蜕膜化障碍的机制研究",
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"no": 2086,
"unit": "浙江大学",
"pi": "朱婷婷",
"name": "衰老介导的p21high巨噬细胞CXCL9 mRNA稳定性改变在移植肾纤维化中的作用研究",
"code": "QN26H050011",
"cat": "青基项目",
"disc": "医学",
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"pi": "应炜阳",
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"pi": "赵加茜",
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"no": 2089,
"unit": "浙江大学",
"pi": "吴旦斌",
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"no": 2091,
"unit": "浙江大学",
"pi": "程旖",
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"no": 2092,
"unit": "浙江大学",
"pi": "林一峰",
"name": "砷暴露通过E2F1乳酸化修饰调控线粒体自噬促进子宫内膜异位症进展的作用机制研究",
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"no": 2095,
"unit": "浙江大学",
"pi": "唐红",
"name": "AKT抑制剂通过PPM1D-p53信号轴重编程tolDC抗移植排斥作用及其分子机制研究",
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"no": 2096,
"unit": "浙江大学",
"pi": "周圆圆",
"name": "HFPO-DA孕期暴露通过STUB1介导GPX4泛素化降解诱导胎鼠卵巢颗粒细胞铁死亡的机制研究",
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"pi": "柳景文",
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"unit": "浙江大学",
"pi": "王诗芬",
"name": "转录因子SOX8通过增强MDSCs浸润和功能促进DLBCL发展的作用与机制研究",
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"cat": "青基项目",
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"unit": "浙江大学",
"pi": "李若绮",
"name": "去氢茯苓酸调控TREM2/TGF-β1/SMAD3抑制小胶质细胞中脂滴蓄积抗缺血性脑卒中的作用机制研究",
"code": "QN26H280050",
"cat": "青基项目",
"disc": "医学",
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"unit": "浙江大学",
"pi": "史洋",
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"code": "QN26H140025",
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"disc": "医学",
"lines": "细胞/类器官",
"ev": "类器官、细胞",
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"no": 2104,
"unit": "浙江大学",
"pi": "徐唯玮",
"name": "Des1通过囊泡转运关键分子sec24调节SREBP1c蛋白成熟过程促进肝脏胰岛素抵抗的机制研究",
"code": "QN26H070011",
"cat": "青基项目",
"disc": "医学",
"lines": "蛋白表达纯化",
"ev": "蛋白",
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{
"no": 2105,
"unit": "浙江大学",
"pi": "孙戈",
"name": "基于FADS2 rs66698963变异的EPA精准营养干预在结直肠癌预防中的脂质与肠道菌群机制研究",
"code": "QN26H160107",
"cat": "青基项目",
"disc": "医学",
"lines": "未命中",
"ev": "",
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{
"no": 2107,
"unit": "温州医科大学",
"pi": "俞余彬",
"name": "泛素编辑酶A20双靶向修饰STING与VP22促进单纯疱疹病毒性角膜炎进展的机制研究",
"code": "QN26H120003",
"cat": "青基项目",
"disc": "医学",
"lines": "蛋白表达纯化",
"ev": "酶",
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"act": "纳入单位级年度拜访清单，暂不单独立项（项目：泛素编辑酶A20双靶向修饰STING与VP22促）"
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{
"no": 2108,
"unit": "温州医科大学",
"pi": "徐挺挺",
"name": "FPR1作为非经典模式识别受体参与FAM3D驱动的肺内皮屏障损伤的机制研究",
"code": "QN26H010003",
"cat": "青基项目",
"disc": "医学",
"lines": "未命中",
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"act": "纳入单位级年度拜访清单，暂不单独立项（项目：FPR1作为非经典模式识别受体参与FAM3D驱动）"
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{
"no": 2109,
"unit": "温州医科大学",
"pi": "张琛",
"name": "IGF2BP2通过m6A依赖及非依赖途径协同调控CCNB1-CDC25B-MPF轴介导肝癌辐射敏感性的机制研究",
"code": "QN26H220001",
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"disc": "医学",
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"act": "纳入单位级年度拜访清单，暂不单独立项（项目：IGF2BP2通过m6A依赖及非依赖途径协同调控）"
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{
"no": 2114,
"unit": "温州医科大学",
"pi": "黄锦锋",
"name": "“高稳态”线粒体移植逆转巨噬细胞衰老进而促进糖尿病骨再生的作用及机制研究",
"code": "QN26H060007",
"cat": "青基项目",
"disc": "医学",
"lines": "细胞/类器官",
"ev": "细胞",
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"proj_score": 2,
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"act": "纳入单位级年度拜访清单，暂不单独立项（项目：“高稳态”线粒体移植逆转巨噬细胞衰老进而促进糖尿）"
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{
"no": 2115,
"unit": "浙江中医药大学",
"pi": "曹菲薇",
"name": "烟酰胺单核苷酸通过上调Hepcidin减轻肝铁过载改善酒精相关性脂肪肝病的作用机制研究",
"code": "QN26H260013",
"cat": "青基项目",
"disc": "医学",
"lines": "未命中",
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"act": "纳入单位级年度拜访清单，暂不单独立项（项目：烟酰胺单核苷酸通过上调Hepcidin减轻肝铁过）"
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{
"no": 2116,
"unit": "浙江中医药大学",
"pi": "闫岩",
"name": "基于SC-FC耦合探讨针刺对急性脑梗死运动障碍脑网络重塑的时间纵向性研究",
"code": "QN26H270028",
"cat": "青基项目",
"disc": "医学",
"lines": "未命中",
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{
"no": 2121,
"unit": "温州医科大学",
"pi": "张鹏",
"name": "TRPV4/Ca2+信号介导海马神经元突触损伤在脑外伤后认知功能障碍中的机制研究",
"code": "QN26H090016",
"cat": "青基项目",
"disc": "医学",
"lines": "未命中",
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"act": "纳入单位级年度拜访清单，暂不单独立项（项目：TRPV4/Ca2+信号介导海马神经元突触损伤在）"
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{
"no": 2122,
"unit": "浙江大学",
"pi": "张梦涵",
"name": "SIRT3-OSCP介导线粒体嵴重塑调控纤维脂肪祖细胞分化改善老年OSAHS上气道扩张肌再生障碍的机制研究",
"code": "QN26H140029",
"cat": "青基项目",
"disc": "医学",
"lines": "细胞/类器官",
"ev": "细胞",
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"act": "确认课题组采购主体与预算年度；先寄试用装（项目：SIRT3-OSCP介导线粒体嵴重塑调控纤维脂肪）"
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{
"no": 2124,
"unit": "浙江中医药大学",
"pi": "谢卓宓",
"name": "ThERF46启动子InDel变异介导的表观调控在三叶青耐寒性形成中的作用机制研究",
"code": "QN26H280033",
"cat": "青基项目",
"disc": "医学",
"lines": "未命中",
"ev": "",
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"act": "纳入单位级年度拜访清单，暂不单独立项（项目：ThERF46启动子InDel变异介导的表观调控）"
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"no": 2125,
"unit": "浙江中医药大学",
"pi": "赵远",
"name": "三子归巢汤靶向 ESCRT-STING-NF-κB/IRF3 信号轴抑制炎症改善早发性卵巢功能不全的作用机制研究",
"code": "QN26H290014",
"cat": "青基项目",
"disc": "医学",
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"ev": "",
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"act": "纳入单位级年度拜访清单，暂不单独立项（项目：三子归巢汤靶向 ESCRT-STING-NF-κ）"
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{
"no": 2130,
"unit": "浙江大学",
"pi": "郑丹丹",
"name": "靶向肝星状细胞PKM2抑制肝癌发生发展的机制研究",
"code": "QN26H160087",
"cat": "青基项目",
"disc": "医学",
"lines": "细胞/类器官",
"ev": "细胞",
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"act": "确认课题组采购主体与预算年度；先寄试用装（项目：靶向肝星状细胞PKM2抑制肝癌发生发展的机制研究）"
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{
"no": 2131,
"unit": "浙江大学",
"pi": "牛萌柯",
"name": "USP13通过去泛素化修饰SLUG蛋白调控VEGF转录诱导三阴性乳腺癌化疗耐药的机制研究",
"code": "QN26H160099",
"cat": "青基项目",
"disc": "医学",
"lines": "蛋白表达纯化",
"ev": "蛋白",
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"act": "确认课题组采购主体与预算年度；先寄试用装（项目：USP13通过去泛素化修饰SLUG蛋白调控VEG）"
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{
"no": 2132,
"unit": "浙江大学",
"pi": "陈一可",
"name": "TMZ诱导代谢重编程巨噬细胞通过HIF1α-LDHA轴塑造乳酸微环境促进胶质瘤化疗抵抗的机制研究",
"code": "QN26H160124",
"cat": "青基项目",
"disc": "医学",
"lines": "细胞/类器官",
"ev": "细胞",
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{
"no": 2133,
"unit": "浙江大学",
"pi": "沈思",
"name": "EPS15高表达介导II型肺泡上皮细胞炎性衰老在老年IAV重症感染中的作用及机制研究",
"code": "QN26H190014",
"cat": "青基项目",
"disc": "医学",
"lines": "细胞/类器官",
"ev": "细胞",
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"act": "确认课题组采购主体与预算年度；先寄试用装（项目：EPS15高表达介导II型肺泡上皮细胞炎性衰老在）"
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{
"no": 2134,
"unit": "浙江大学",
"pi": "竺越丽",
"name": "CCR2⁺硬脑膜巨噬细胞通过激活T细胞介导阿尔茨海默病中脑膜淋巴管功能障碍的机制研究",
"code": "QN26H250005",
"cat": "青基项目",
"disc": "医学",
"lines": "细胞/类器官",
"ev": "细胞",
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"act": "确认课题组采购主体与预算年度；先寄试用装（项目：CCR2⁺硬脑膜巨噬细胞通过激活T细胞介导阿尔茨）"
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{
"no": 2135,
"unit": "浙江大学",
"pi": "汪艳红",
"name": "eEF1A甲基转移酶eEF1AKMT1介导mRNA选择性翻译以促进三阴性乳腺癌转移的机制研究",
"code": "QN26H310028",
"cat": "青基项目",
"disc": "医学",
"lines": "蛋白表达纯化、mRNA/核酸药",
"ev": "mRNA、酶",
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"act": "确认课题组采购主体与预算年度；先寄试用装（项目：eEF1A甲基转移酶eEF1AKMT1介导mRN）"
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{
"no": 2136,
"unit": "浙江大学",
"pi": "吕佳兰",
"name": "骨架蛋白Cypher抑制平滑肌细胞表型转化参与主动脉瘤发生发展的作用及机制研究",
"code": "QN26H020028",
"cat": "青基项目",
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